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Study suggests two copies of APOE4 gene behind up to 20% of Alzheimer’s cases

Study suggests two copies of APOE4 gene behind up to 20% of Alzheimer's cases

Penetrance and predictive value of APOE4 homozygosity in AD. a, Distribution of ADNC scores by age of death. b, Frequency of positive amyloid and tau biomarkers across 5-year age intervals. c, Overview of the mean and 95% confidence interval ages at which symptoms, MCI and dementia manifest. d, The 95% prediction intervals for various genetically determined forms of AD….


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