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in Health

Porous cells lead to poorer livers

by Editor June 24, 2022, 6:29 pm 1.5k Views

Porous cells lead to poorer livers

High-fat diets weaken gut barrier function, resulting in the migration and accumulation of lipoteichoic acid in the liver. The accumulated lipoteichoic acid stimulates the cleavage of gasdermin D protein, forming cell membrane pores where the SASP factors IL-1β and IL-33 are released from hepatic stellate cells. IL-33 activates regulatory T cells that suppress immune…

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