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Newly discovered mechanism halts tumor cell replication

Newly discovered mechanism halts tumor cell replication

Top1ccs induce dynamic changes of hybrid levels at specific genomic sites in HCT116 cells. Credit: Science Advances (2024). DOI: 10.1126/sciadv.adm8196

A research group at the University of Bologna has identified, for the first time, the specific location and genomic context where DNA breaks occur due to the inhibition of the topoisomerase I, a…


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