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in Health

New insights into metabolic and immune pathway interactions in obesity

by Editor July 7, 2024, 10:15 am 999 Views

TBC1D1 is an energy-responsive polarization regulator of macrophages via governing ROS production in obesity

A diagrammatic illustration represents the proposed model. The energy sensor AMPK becomes less active under energy overload conditions, which leads to hypophosphorylation of TBC1D1. Hypophosphorylated TBC1D1 is more active and converts Rab8a to its GDP-bound form. TBC1D1 and GDP-bound Rab8a interacts with NOX2, and enhances its enzymatic activity to generate ROS, which…

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