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in Health

New drug candidates targeting blood clots developed through computer-aided drug design

by Editor June 11, 2024, 8:43 pm 1.6k Views

(A) Red boxes follow lead optimization of 3 through 4 and 5 indole series; light blue designates imidazothiadiazole series from BMS starting with BMS-3 (2) from the HTS and BMS-986120 (1) in clinical trials; purple designates the chimerization series of the indole and imidazothiadiazole series (6). (B) Predicted binding mode of BMS-3 (green). Comparison to experimentally…

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