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Overexpressed Cyclin D1 and CDK4 proteins are responsible for the resistance to CDK4/6 inhibitor in some breast cancer

by Editor September 18, 2022, 9:03 pm 1.7k Views

Overexpressed Cyclin D1 and CDK4 proteins are responsible for the resistance to CDK4/6 inhibitor in breast cancer that can be re

The CDK4/6 inhibitors-resistant breast cancer cells expressed more Cyclin D1 and CDK4 proteins than the parental cells (Upper left). PI3K pathway was hyper-activated in the resistant cells (Upper right). Targeting PI3K/mTOR pathway with BYL719 (BYL, PI3Kα inhibitor） or everolimus （EVMS，mTOR inhibitor）reduced CDK4 and Cyclin D1 expression (Lower left) and restored…

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